November 20, 2025

Immatics shares early bispecific data as it seeks to make its name beyond cell therapy

IntelME Verdict

Clinical Progress

TL;DR

Immatics showcases promising early clinical data on TCR bispecifics IMA401 and IMA402, expanding beyond cell therapy and establishing leadership in PRAME-targeting therapies.

Analysis

Immatics' early clinical data on TCR bispecifics IMA401 and IMA402, showing promising response rates in heavily pretreated solid tumor patients, positions the company as a leader in PRAME-targeting therapies. Bristol Myers Squibb's exit and Immatics' plans for further development and combination trials indicate significant potential for advancing bispecific platforms in oncology.

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